Hepatoprotective effects of bergenin, a major constituent of Mallotus japonicus, on carbon tetrachloride-intoxicated rats

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• 作者：Lim ; Hwa-Kyung ; Kim ; Hack-Seang ; Choi ; Hong-Serck ; Oh ; Seikwan ; Choi ; Jongwon
• 关键词：Bergenin ; Mallotus japonicus ; Carbon tetrachloride ; Hepatoprotective effect
• 刊名：Journal of Ethnopharmacology
• 出版年：2000
• 出版时间：October, 2000
• 年：2000
• 卷：72
• 期：3
• 页码：469-474
• 全文大小：136 K

文摘

The hepatoprotective effects of bergenin, a major constituent of Mallotus japonicus, were evaluated against carbon tetrachloride (CCl₄)-induced liver damage in rats. Bergenin at a dose of 50, 100 or 200 mg/kg was administered orally once daily for successive 7 days and then a mixture of 0.5 ml/kg (ip) of CCl₄ in olive oil (1:1) was injected two times each at 12 and 36 h after the final administration of bergenin. The substantially elevated serum enzymatic activities of alanine/aspartate aminotransferase, sorbitol dehydrogenase and γ-glutamyltransferase due to CCl₄ treatment were dose dependently restored towards normalization. Meanwhile, the decreased activities of glutathione S-transferase and glutathione reductase were restored towards normalization. In addition, bergenin also significantly prevented the elevation of hepatic malondialdehyde formation and depletion of reduced glutathione content in the liver of CCl₄-intoxicated rats in a dose dependent fashion. The results of this study clearly indicate that bergenin has a potent hepatoprotective action against CCl₄-induced hepatic damage in rats.