BA321, a novel carborane analog that binds to androgen and estrogen receptors, acts as a new selective androgen receptor modulator of bone in male mice
详细信息 查看全文
- 作者：Kenta Watanabea ; b ; Michiko Hirataa ; Tsukasa Tominaria ; c ; Chiho Matsumotoa ; Yasuyuki Endod ; Gillian Murphye ; Hideaki Nagasec ; f ; Masaki Inadaa ; b ; c ; Chisato Miyauraa ; b ; c ; miyaura@cc.tuat.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：Osteoporosis ; Bone mass ; Carborane compound ; Estrogen ; Androgen ; Orchidectomized mice ; Selective androgen receptor modulator
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：9 September 2016
- 年：2016
- 卷：478
- 期：1
- 页码：279-285
- 全文大小：1214 K
文摘
- •
A novel carborane compound BA321 binds to both AR and ERs, ERα and ERβ.
- •
BA321 restores bone loss in orchidectomized mice without effects on sex organ.
- •
BA321 acts as an estrogen agonist in bone and uterus in ovariectomized mice.
- •
BA321 may be a new SARM to prevent the loss of musculoskeletal mass in elder men.