Vitamin D supplementation reduces relapse rate in relapsing-remitting multiple sclerosis patients treated with natalizumab
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- 作者：Julie Hejgaard Laursen ; juliehejgaard@hotmail.com ; Helle Bach Sø ; ndergaard ; Per Soelberg Sø ; rensen ; Finn Sellebjerg ; Annette Bang Oturai
- 关键词：Multiple sclerosis ; 25-hydroxyvitamin D ; Vitamin D3 supplement ; Annualized relapse-rate ; Immunomodulation
- 刊名：Multiple Sclerosis and Related Disorders
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：10
- 期：Complete
- 页码：169-173
- 全文大小：198 K
- 卷排序：10
文摘
Recommending vitamin D3 supplements in vitamin D insufficient, relapsing-remitting MS patients is associated with increased 25-hydroxyvitamin D (25(OH)D) levels. Increased 25(OH)D levels in these patients are associated with decreases in the annualized relapse rate (ARR). No association was found between changes in 25(OH)D and changes in gene expression of molecules representing the immune system. This reflects how complex vitamin D research is.