RNA sequencing of pancreatic adenocarcinoma tumors yields novel expression patterns associated with long-term survival and reveals a role for ANGPTL4
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- 作者：Marie K. Kirbya ; 1 ; Ryne C. Ramakera ; b ; 1 ; Jason Gertza ; 2 ; Nicholas S. Davisa ; 3 ; Bobbi E. Johnstona ; Patsy G. Oliverb ; Katherine C. Sextonb ; Edward W. Greenoc ; John D. Christeinb ; Martin J. Heslinb ; James A. Poseyb ; William E. Grizzleb ; Selwyn M. Vickersb ; Donald J. Buchsbaumb ; Sara J. Coopera ; Richard M. Myersa ; rmyers@hudsonalpha.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：Pancreatic adenocarcinoma ; ANGPTL4 ; Gemcitabine ; RNA-seq
- 刊名：Molecular Oncology
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：10
- 期：8
- 页码：1169-1182
- 全文大小：1464 K
文摘
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RNA expression patterns are associated with pancreatic cancer patient survival time.
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A 19-transcript model can predict patient survival time in multiple cohorts.
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A subset of survival transcripts is associated with gemcitabine response in vitro.
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Reduced expression of ANGPTL4 impairs growth of a gemcitabine resistant cell line.