Synthesis and biological activity of some new benzoxazoles

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• 作者：&#xd6 ; zlem Temiz-Arpacı ; İ ; lkay Yı ; ldı ; z ; Semiha &#xd6 ; zkan ; Fatma Kaynak ; Esin Akı ; -Ş ; ener ; İ ; smail Yalç ; ı ; n
• 关键词：Benzoxazoles ; Antifungal activity ; Antibacterial activity
• 刊名：European Journal of Medicinal Chemistry
• 出版年：2008
• 出版时间：July 2008
• 年：2008
• 卷：43
• 期：7
• 页码：1423-1431
• 全文大小：219 K

文摘

The synthesis and antimicrobial activity of a new series of 5-ethylsulphonyl-2-(substituted-phenyl/substituted-benzyl and/or phenylethyl)benzoxazole derivatives (3a–3t) except 3a, 3g, 3h, 3k [R.S. Pottorf, N.K. Chadha, M. Katkevies, V. Ozola, E. Suna, H. Ghane, T. Regberg, M.R. Player, Tetrahedron Lett. 44 (1) (2003) 175] were described. The in vitro antimicrobial activity of the compounds was determined against some Gram-positive, Gram-negative bacteria, a fungi Candida albicans and their drug-resistant isolates in comparison with standard drugs. Antimicrobial results indicated that the synthesized compounds possessed a broad spectrum of activity with MIC values 250–7.81 μg/ml. While all compounds are less potent than fluconazole against C. albicans, most of them are more potent than fluconazole against C. albicans isolate.