Studies on pyrrolidinones. synthesis of fused 1,5-naphthyridines

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• 作者：Rufine Akué ; -Gé ; du^a ; ^b ; Daniel Couturier^a ; ^c ; Jean-Pierre Hé ; nichart^a ; Benoî ; t Rigo^a ; ^b ; ^{benoit.rigo@hei.fr} ; Gerard Sanz^d ; Luc Van Hijfte^d ; Anne Bourry^a ; ^b
• 关键词：Pyroglutamic acid ; Fused indolizinediones ; Fused 1 ; 5-naphthyridines ; Semmler&ndash ; Wolf rearrangement ; N-Acyliminium
• 刊名：Tetrahedron
• 出版年：2012
• 出版时间：8 July, 2012
• 年：2012
• 卷：68
• 期：27-28
• 页码：5644-5654
• 全文大小：526 K

文摘

The synthesis of new condensed indolizinediones derived from pyroglutamic acid is described. The?Semmler-Wolff transposition of the oxime of these ketones leads to fused dihydro-1,5-naphthyridinones. Easy introduction of side amino chains indicates that potential DNA-intercalating heterocyclic systems fused on 1,5-naphthyridine nucleus could be obtained in these series.