SOX2 function and Hedgehog signaling pathway are co-conspirators in promoting androgen independent prostate cancer

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• 作者：Swayamsiddha Kar ; Dipta Sengupta ; Moonmoon Deb¹ ; Nibedita Pradhan ; Samir Kumar Patra ; ^{samirp@nitrkl.ac.in} ; ^{skpatra_99@yahoo.com}
• 关键词：Cell signaling ; Transcription factor ; Prostate cancer ; Gene silencing ; HH signaling ; SOX2
• 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：1863
• 期：1
• 页码：253-265
• 全文大小：2826 K
• 卷排序：1863

文摘

HH signaling and SOX2 function are inclined to developmental cues and arbitrating malignant growth. SOX2 inhibition reduces cell proliferation and induces apoptosis. Conjoint inhibition of SOX2 and HH pathway induce apoptosis, reduce proliferation and migration. This inhibition decrease in E-cadherin and Bcl-2 and increase Bax expression. HH-SOX2 axis is a better therapeutic target than individual treatment policies.