How does the ketogenic diet induce anti-seizure effects?

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• 作者：Jong M. Rho ; ^{jong.rho@albertahealthservices.ca} ; ^{jmrho@ucalgary.ca}
• 关键词：Ketogenic diet ; Epilepsy ; Mechanism ; Metabolism ; Mitochondria ; Oxidative stress
• 刊名：Neuroscience Letters
• 出版年：2017
• 出版时间：10 January 2017
• 年：2017
• 卷：637
• 期：Complete
• 页码：4-10
• 全文大小：890 K
• 卷排序：637

文摘

Clinical and experimental interest in the ketogenic diet has grown rapidly over the past decade. Ketone bodies have been linked to inhibitory neurotransmitter release and activation of ATP-sensitive potassium channels. The ketogenic diet enhances overall cellular bioenergetics and reduces oxidative stress. Glycolytic diversion and/or restriction may play an important role in the clinical activity of the ketogenic diet. Modulation of tricarboxylic acid cycle flux may also underlie ketogenic diet effects.