pH-sensitive polymeric cisplatin-ion complex with styrene-maleic acid copolymer exhibits tumor-selective drug delivery and antitumor activity as a result of the enhanced permeability and retention effect
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- 作者：Atsuyuki Saisyoa ; b ; Hideaki Nakamurac ; d ; Jun Fangc ; d ; e ; fangjun@ph.sojo-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Kenji Tsukigawad ; Khaled Greishf ; g ; Hiroyuki Furukawaa ; b ; Hiroshi Maedac ; hirmaeda@ph.sojo-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cisplatin ; Styrene-maleic acid copolymer ; Tumor environment-sensitive drug delivery ; Tumor-selective drug delivery ; EPR effect
- 刊名：Colloids and Surfaces B: Biointerfaces
- 出版年：2016
- 出版时间：1 February 2016
- 年：2016
- 卷：138
- 期：Complete
- 页码：128-137
- 全文大小：1881 K
文摘
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Polymer complex of CDDP with styrene-maleic acid-copolymer, SMA–CDDP was synthesized.
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SMA–CDDP behaves as polymeric micelle with particle size of 102.5 nm.
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Release of CDDP from SMA–CDDP exhibits pH-dependency: higher release at acidic pH.
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SMA–CDDP showed 5-time higher tumor accumulation than free CDDP based on EPR effect.
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Remarkable in vivo antitumor effect was achieved by SMA–CDDP with less side effect.