Intravaginal administration of metformin hydrochloride loaded cationic niosomes amalgamated with thermosensitive gel for the treatment of polycystic ovary syndrome: In vitro and in vivo studies
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- 作者：Neetu Sainia ; Rupinder Kaur Sodhib ; Lotika Bajaja ; Ravi Shankar Pandeyc ; Upendra Kumar Jaina ; Om Prakash Katared ; Jitender Madana ; jitenderpharmacy@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Polycystic ovary syndrome ; Metformin hydrochloride ; Cationic niosomes ; Thermosensitive gel ; Sustained release
- 刊名：Colloids and Surfaces B: Biointerfaces
- 出版年：2016
- 出版时间：1 August 2016
- 年：2016
- 卷：144
- 期：Complete
- 页码：161-169
- 全文大小：1774 K
文摘
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Thermosensitive gel of metformin offered sustained release through vaginal route.
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Metformin regulated the hormones in experimental polycystic ovary syndrome.
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Intravaginal metformin administration surmounted the biopharmaceutical limitations.