Mechanisms of temperature sensitivity of attenuated Urabe mumps virus

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• 作者：Stephanie C. Burke Schinkel^a ; ^{sburk089@uottawa.ca} ; Steven Rubin^b ; ^{rubins@ceber.FDA.gov} ; Kathryn E. Wright^a ; ^{kwright@uottawa.ca}
• 关键词：Mumps virus ; Attenuation ; Temperature sensitivity ; Transcription ; Replication
• 刊名：Virus Research
• 出版年：2017
• 出版时间：2 January 2017
• 年：2017
• 卷：227
• 期：Complete
• 页码：104-109
• 全文大小：1442 K
• 卷排序：227

文摘

Attenuation of viruses is often linked to temperature sensitivity. A temperature sensitive isolate of Urabe mumps virus was shown to be attenuated. Genetic substitutions unique to this virus were identified including changes in the virus polymerase. Functioning of the viral RNA polymerase was reduced at the non-permissive temperature.