Inflamed skin predisposes to sensitization to less potent allergens

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• 作者：Nita Kohli ; MD ; MPH ; Susan Nedorost ; MD ; ^{stn@case.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：atopic dermatitis ; contact sensitization ; irritant dermatitis ; occupational hand dermatitis ; potency of contact allergens ; systemic contact dermatitis ; wet work
• 刊名：Journal of the American Academy of Dermatology
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：75
• 期：2
• 页码：312-317.e1
• 全文大小：153 K

文摘

Irritant dermatitis, caused by genetic barrier dysfunction in atopic dermatitis or wet work in hand dermatitis, induces innate immune response that might predispose to allergic contact sensitization to less potent sensitizers.

Objectives

We sought to determine if positive patch test results to less potent allergens are more prevalent in patients with a history of childhood flexural dermatitis or current wet work.

Methods

We examined our database of patients presenting to a contact dermatitis clinic tested to potential contact allergens as indicated by their history. Allergens from our most recent standard were studied if they could be classified as weak, moderate, or strong sensitizers based on published data from the local lymph node assay. Patients were stratified by a history of childhood-onset flexural dermatitis as a proxy for atopic dermatitis and by occupation.

Results

History of childhood-onset dermatitis predisposed to contact allergy to weak sensitizers and wet work to medium-potency sensitizers. Neither predisposed to contact allergy from strong sensitizers.

Limitations

Association cannot prove causation.

Conclusions

We conclude that strong sensitizers do not require wet work or atopy to cause sensitization. Barrier defects associated with childhood eczema and wet work may promote sensitization to weak antigens.