Evidence of memory generalization in contextual locomotor sensitization induced by amphetamine
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- 作者：Douglas Senna Engelkea ; douglas.engelke@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Renato Fileva ; Luiz E. Melloa ; Jair Guilherme Santos-Juniora ; b
- 关键词：Addiction ; Amphetamine ; Behavioral sensitization ; Contextual memory ; Drugs ; Psychostimulants
- 刊名：Behavioural Brain Research
- 出版年：2017
- 出版时间：15 January 2017
- 年：2017
- 卷：317
- 期：Complete
- 页码：522-527
- 全文大小：1091 K
文摘
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After 3 days of withdrawal, amphetamine sensitization is context-dependent.
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After 28 days of withdrawal, animals expressed a generalized locomotor activity in novel context.
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Contextual generalization is prevented when sensitization was conducted in a well-known context.
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Memory generalization phenomena should be considered in studies of addiction.