Piezoresistive sensor-integrated PDMS cantilever: A new class of device for measuring the drug-induced changes in the mechanical activity of cardiomyocytes

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• 作者：Dong-Su Kim^aAuthor Vitae ; Yun-Jin Jeong^aAuthor Vitae ; Bong-Kee Lee^bAuthor Vitae ; Arunkumar Shanmugasundaram^bAuthor Vitae ; Dong-Weon Lee^b ; ^{mems@jnu.ac.kr}Author Vitae
• 关键词：Cardiomyocyte ; PDMS cantilever ; Strain sensor ; Microgroove ; Contraction force ; Mechanical activity of cardiomyocytes
• 刊名：Sensors and Actuators B: Chemical
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：240
• 期：Complete
• 页码：566-572
• 全文大小：1648 K
• 卷排序：240

文摘

This article proposes a strain sensor-integrated PDMS cantilever for measuring the drug induced changes in the mechanical activity of cardiomyocytes. Integration of the strain sensor eliminate the use of an external optical measurement system. Electrical reliability of the sensor is greatly improved by using a glass body with metal patterns. Microgrooves formed on the PDMS cantilever effectively align the cardiomyocytes and maximize their contraction force. The cantilever deflection caused by the contraction force of the cardiomyocytes is successfully measured using the integrated strain sensor in real time.