Enhancing inhibitory synaptic function reverses spatial memory deficits in Shank2 mutant mice
详细信息 查看全文
- 作者：Chae-Seok Lima ; 1 ; Hyopil Kima ; 1 ; Nam-Kyung Yua ; 1 ; Sukjae Joshua Kanga ; 1 ; TaeHyun Kima ; Hyoung-Gon Koa ; Jaehyun Leea ; Jung-eun Yanga ; Hyun-Hee Ryub ; c ; Taesung Parkd ; Jungsoo Gimd ; Hye Jin Name ; Sung Hee Baeke ; Stephanie Wegenerf ; Dietmar Schmitzf ; Tobias M. Boeckersg ; Min Goo Leeh ; Eunjoon Kimi ; Jae-Hyung Leej ; jaehlee@khu.ac.kr" class="auth_mail" title="E-mail the corresponding author ; Yong-Seok Leec ; yongseok7@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Bong-Kiun Kaanga ; kaang@snu.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Autism spectrum disorders ; Shank2 ; Gabra2 ; I/E ratio ; Spatial memory
- 刊名：Neuropharmacology
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：112
- 期：part_PA
- 页码：104-112
- 全文大小：1491 K
文摘
- •
Expression of Gabra2 gene coding GABAA receptor α2 subunit was reduced in Shank2 e6-7 KO mice, but not in Shank2 e7 KO mice.
- •
GABAA receptor-mediated synaptic transmission was impaired in Shank2 e6-7 KO mice, resulting in reduced I/E ratio.
- •
A GABAA receptor α2 agonist L838,417 restored the impaired I/E ratio in Shank2 e6-7 KO mice.
- •
L838,417 treatment reversed spatial memory deficits in Shank2 e6-7 KO mice without affecting the social deficit.