Subchronic toxicity of Acorus gramineus rhizoma in rats

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• 作者：Yong-Hoon Lee^a ; ^b ; Duyeol Kim^a ; Mi Ju Lee^a ; Myoung Jun Kim^a ; Ho-Song Jang^a ; Sun Hee Park^a ; Jung-Min Lee^a ; ^e ; Hye-Yeong Lee^a ; Cheol-Beom Park^a ; Beom Seok Han^c ; Woo-Chan Son^d ; Jin Seok Kang^e ; ^{kang@nsu.ac.kr" class="auth_mail" title="E-mail the corresponding author} ; Jong-Koo Kang^a ; ^f ; ^{jkkang@cbu.ac.kr" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Acorus gramineus ; Fischer 344 rat ; subchronic toxicity
• 刊名：Journal of Ethnopharmacology
• 出版年：2016
• 出版时间：13 May 2016
• 年：2016
• 卷：183
• 期：Complete
• 页码：46-53
• 全文大小：290 K

文摘

Acorus gramineus rhizoma (AGR) is the dry rhizome of Acorus gramineus Solander from the family Araceae that has been used as sedative, analgesic, diuretic, digestive and antifungal agent.

Aim of the study

To evaluate the no-observed-adverse-effect level (NOAEL) and the toxicity of AGR, following repeated oral administration to rats for 13 weeks.

Materials and methods

AGR was administered by oral gavage to groups of rats (10 per group, each sex) at doses of 0 (control), 25, 74, 222, 667, or 2,000 mg/kg/day, 5 times per week for 13 weeks. Mortality, clinical signs, body weights, food consumption, hematology, serum chemistry, urinalysis, vaginal cytology, sperm motility, sperm morphology, organ weights, gross and histopathological findings were compared between control and AGR groups.

Results

No mortality or remarkable clinical signs were observed during this 13-week study. No adverse effects on body weight, food consumption, urinalysis, hematology, serum chemistry, organ weights, gross lesion, histopathology, vaginal cytology, sperm motility or deformity were observed in any of the male or female rats treated with AGR.

Conclusions

On the basis of these results, the NOAEL of AGR is determined to be 2,000 mg/kg/day for male and female rats.