Tsp66E, the Drosophila KAI1 homologue, and Tsp74F function to regulate ovarian follicle cell and wing development by stabilizing integrin localization

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• 作者：Seung Yeop Han^a ; ¹ ; Minjung Lee^a ; ¹ ; Yoon Ki Hong^a ; Soojin Hwang^a ; Gahee Choi^a ; Yoon Seok Suh^a ; Seung Hwan Park^a ; Soojin Lee^a ; Sang-Hee Lee^b ; Jongkyeong Chung^b ; Sung Hee Baek^c ; Kyoung Sang Cho^a ; ^{kscho@konkuk.ac.kr}
• 关键词：KAI1 ; kangai1 ; if ; inflated ; PS ; position specific ; Tsp ; tetraspanin
• 刊名：FEBS Letters
• 出版年：2012
• 出版时间：16 November, 2012
• 年：2012
• 卷：586
• 期：22
• 页码：4031-4037
• 全文大小：1122 K

文摘

The metastasis suppressor KAI1/CD82 has been implicated in various cellular processes; however, its function in development is not fully understood. Here, we generated and characterized mutants of Tsp66E and Tsp74F, which are Drosophila homologues of KAI1/CD82 and Tspan11, respectively. These mutants exhibited egg elongation defects along with disturbed integrin localization and actin polarity. Moreover, the defects were enhanced by mutation of inflated, an ¦ÁPS2 integrin gene. Mutant ovaries had elevated ¦ÁPS2 integrin levels and reduced endocytic trafficking. These results suggest that Drosophila KAI1/CD82 affects the polarized localization and the level of integrin, which may contribute to epithelial cell polarity.