Cholangiocarcinoma and Clonorchis sinensis infection: A case–control study in Korea

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• 作者：Dongil Choi ; Jae Hoon Lim ; Kyu Taek Lee ; Jong Kyun Lee ; Seong Ho Choi ; Jin Seok Heo ; Kee-Taek Jang ; Nam Yong Lee ; Seonwoo Kim and Sung-Tae Hong
• 刊名：Journal of Hepatology
• 出版年：2006
• 出版时间：June 2006
• 年：2006
• 卷：44
• 期：6
• 页码：1066-1073
• 全文大小：261 K

文摘

Background/Aims

The authors conducted a hospital-based case–control study to evaluate the role of Clonorchis sinensis infection as a risk factor for the development of cholangiocarcinoma (CC), including extrahepatic CC, in Korea.

Methods

Cases of 185 patients with CC (intrahepatic, 51; hilar, 53; and distal extrahepatic, 81) and matched controls underwent stool microscopy, pathological examinations, serologic test for C. sinensis using ELISA, skin test for C. sinensis, radiologic examinations, and interview concerning history of eating raw freshwater fish.

Results

Radiologic evidence of C. sinensis, history of eating raw freshwater fish, and positive serologic result for C. sinensis were found to be related to an increased risk of CC, with the odds ratios (OR)=8.615 (95 % confidence interval [CI]=5.045–16.062), OR=2.385 (95 % CI=1.527–3.832), and OR=2.272 (95 % CI=1.147–4.811), respectively. The risk factors for distal extrahepatic CC were radiologic evidence of C. sinensis (OR=6.571; 95 % CI=3.170–15.943) and history of eating raw freshwater fish (OR=2.6; 95 % CI=1.294–5.66).

Conclusions

Radiologic evidence of C. sinensis, history of eating raw freshwater fish and positive serologic result for C. sinensis were significantly associated with CC, including extrahepatic CC.