Interplay between the chalcone cardamonin and selenium in the biosynthesis of Nrf2-regulated antioxidant enzymes in intestinal Caco-2 cells
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- 作者：Silke De Spirta ; Anna Eckersa ; b ; Carina Wehrenda ; Mustafa Micoogullaria ; Helmut Siesa ; b ; c ; Wilhelm Stahla ; Holger Steinbrennera ; d ; Holger.Steinbrenner@uni-jena.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：ARE ; antioxidant response element ; GPx ; glutathione peroxidase ; HO-1 ; heme oxygenase 1 ; MeHg ; methylmercury ; Nrf2 ; nuclear factor erythroid 2-related factor 2 ; PSTK ; O-phosphoseryl-tRNA(Sec) kinase ; Sec ; selenocysteine ; SepSecS ; O-phosphoseryl-tRNA(Sec) selenium transferase ; SPS-2 ; selenophosphate synthetase 2 ; TrxR ; thioredoxin reductase
- 刊名：Free Radical Biology and Medicine
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：91
- 期：Complete
- 页码：164-171
- 全文大小：1259 K
文摘
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Cardamonin induces gene expression of the Nrf2 target genes HO-1, GPx2 and TrxR1 in Caco-2 cells.
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Cardamonin interferes with the translation of selenoprotein mRNAs.
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Cardamonin-induced stimulation of HO-1 biosynthesis is diminished in Se-supplemented compared to Se-deficient cells.