Cardamonin induces gene expression of the Nrf2 target genes HO-1, GPx2 and TrxR1 in Caco-2 cells.
Cardamonin interferes with the translation of selenoprotein mRNAs.
Cardamonin-induced stimulation of HO-1 biosynthesis is diminished in Se-supplemented compared to Se-deficient cells.