Simple and efficient methodology to prepare guanidines from 1,3-disubstituted thioureas
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- 作者：Má ; rcio V. Costa ; Lú ; cia Cruz de Sequeira Aguiar ; luciasequeira@yahoo.com.br" class="auth_mail" title="E-mail the corresponding author ; Luiz Fernando B. Malta ; Gil M. Viana ; Bruno B.S. Costa
- 关键词：Guanidines ; Potassium dichloroiodate ; Thioureas ; Guanylating agent ; Carbodiimides
- 刊名：Tetrahedron Letters
- 出版年：2016
- 出版时间：6 April 2016
- 年：2016
- 卷：57
- 期：14
- 页码：1585-1588
- 全文大小：643 K
文摘
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KICl2 was used to obtain guanidinium salts from 1,3-disubstituted thioureas.
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Cyclic/acyclic guanidines (hydrochloride salt) were obtained in high chemical yields.
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The aqueous solution of KICl2 offers advantages in terms of safety and ease of use.