CtIP Maintains Stability at Common Fragile Sites and Inverted Repeats by End Resection-Independent Endonuclease Activity
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- 作者：Hailong Wang1 ; 8 ; 9 ; Yongjiang Li1 ; 9 ; Lan N. Truong1 ; Linda Z. Shi2 ; Patty Yi-Hwa Hwang1 ; Jing He1 ; Johnny Do1 ; Michael Jeffrey Cho1 ; Hongzhi Li4 ; Alejandro Negrete5 ; Joseph Shiloach5 ; Michael W. Berns2 ; 3 ; Binghui Shen6 ; Longchuan Chen7 ; Xiaohua Wu1 ; xiaohwu@scripps.edu" class="auth_mail
- 刊名：Molecular Cell
- 出版年：19 June 2014
- 年：2014
- 卷：54
- 期：6
- 页码：1012-1021
- 全文大小：2626 K
文摘
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AT-rich CFS sequences and inverted Alu repeats induce mitotic recombination
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Human CtIP exhibits an endonuclease activity that is dispensable for end resection
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The CtIP endonuclease activity is required for repairing structure-forming DSBs
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The nuclease activities of CtIP and Mre11 are important for CFS protection