Everolimus improves memory and learning while worsening depressive- and anxiety-like behavior in an animal model of depression
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- 作者：Emilio Russoa ; erusso@unicz.it" class="auth_mail" title="E-mail the corresponding author ; Antonio Leoa ; Rosalia Crupib ; Rossana Aielloa ; Pellegrino Lippielloc ; Rosangela Spigad ; Serafina Chimirria ; Rita Citraroa ; Salvatore Cuzzocreab ; Andrew Constantie ; Giovambattista De Sarroa
- 关键词：Depression ; Anxiety ; Cognitive function ; mTOR ; Neurogenesis ; Mice
- 刊名：Journal of Psychiatric Research
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：78
- 期：Complete
- 页码：1-10
- 全文大小：1337 K
文摘
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The effects of everolimus on animal behavior and neurogenesis were investigated.
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Everolimus had detrimental effects on depressive and anxiety-like behavior in mice.
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Everolimus, increasing neurogenesis, had positive effects on memory performance.
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mTOR inhibitors might improve cognitive function or protect from cognitive decline.
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Caution in the clinical use of everolimus, above all in the developing brain.