Novel rhodium catalyst for asymmetric hydroformylation of styrene: Study of electronic and steric effects of phosphorus seven-membered ring ligands
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- 作者：Giulia Erre ; Stephan Enthaler ; Kathrin Junge ; Serafino Gladiali ; Matthias Beller
- 关键词：Asymmetric hydroformylation ; Rhodium ; Monodentate phosphines
- 刊名：Journal of Molecular Catalysis A: Chemical
- 出版年：2008
- 出版时间：4 February 2008
- 年：2008
- 卷：280
- 期：1-2
- 页码：148-155
- 全文大小：700 K
文摘
The asymmetric hydroformylation of styrene catalysed by rhodium complexes modified by monodentate phosphepine ligands has been investigated. The effects of a systematic variation of the phosphorus substituent on catalytic activity and selectivity are reported as well as the outcome of a combinatorial approach for the formation of mixed ligands complexes with several commercially available ligands. Effective catalytic systems have been devised for the reaction that provide for full conversion within 24 h and regioselectivity up to 96 % in the branched aldehyde and enantioselectivities up to 48 % . The use of bidentate ligands built up by binaphthyl-supported seven-membered phosphacyclic units does not allow for further improvement in the reaction outcome.