Technetium-99m-labeled ceftizoxime loaded long-circulating and pH-sensitive liposomes used to identify osteomyelitis
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- 作者：Soraya Maria Z ; im Maciel Dias Ferreira ; Giselle Pires Domingos ; Diego dos Santos Ferreira ; Talita Guieiro Ribeiro Rocha ; Rog¨¦ria Serakides ; Cleuza Maria de Faria Rezende ; Valbert Nascimento Cardoso ; Simone Od¨ªlia Antunes Fern ; es ; M?nica Cristina Oliveira
- 关键词：Ceftizoxime ; Long-circulating and pH-sensitive liposomes ; Technetium-99m ; Inflammation ; Osteomyelitis
- 刊名：Bioorganic and Medicinal Chemistry Letters
- 出版年：2012
- 出版时间：15 July, 2012
- 年：2012
- 卷：22
- 期：14
- 页码：4605-4608
- 全文大小：328 K
文摘
Osteomyelitis is an infectious disease located in the bone or bone marrow. Long-circulating and pH-sensitive liposomes containing a technetium-99m-labeled antibiotic, ceftizoxime, (SpHL-99mTc-CF) were developed to identify osteomyelitis foci. Biodistribution studies and scintigraphic images of bone infection or non infection-bearing rats that had been treated with these liposomes were performed. A high accumulation in infectious foci and high values in the target-non target ratio could be observed. These results indicate the potential of SpHL-99mTc-CF as a potential agent for the diagnosis of bone infections.