Normal tissue considerations and dose-volume constraints in the moderately hypofractionated treatment of non-small cell lung cancer

详细信息    查看全文

• 作者：Cathy Fleming^a ; ^b ; ; Daniel N. Cagney^c ; Serena O&rsquo ; Keeffe^a ; ^b ; Sinead M. Brennan^c ; John G. Armstrong^c ; Brendan McClean^a
• 关键词：NSCLC ; DVCs ; Dose&ndash ; volume constraints ; Toxicity ; Hypofractionated
• 刊名：Radiotherapy and Oncology
• 出版年：2016
• 出版时间：June 2016
• 年：2016
• 卷：119
• 期：3
• 页码：423-431
• 全文大小：1364 K

文摘

Hypofractionated radiation therapy (RT) regimes in non-small cell lung cancer (NSCLC) have become increasingly popular with a number of international trials currently underway. The majority of the dose–volume-constraints (DVCs) published in the literature refer to conventional 2 Gy per fraction deliveries. Here relevant organs-at-risk (OARs) are identified and available dose–volume constraint data discussed and summarised for moderately hypofractionated NSCLC regimes. The OARs examined include lung, brachial plexus, heart, oesophagus, airway and spinal cord. Where available the toxicity rates are also reported with all data summarised tabulated to aid its use in the clinic.