New insights into IGF-1 signaling in the heart

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• 作者：Rodrigo Troncoso¹ ; ² ; ^* ; Cristiá ; n Ibarra³ ; ^* ; Jose Miguel Vicencio⁴ ; Enrique Jaimovich² ; Sergio Lavandero¹ ; ² ; ⁵ ; ^{slavander@uchile.cl" class="auth_mail} ; ^{sergiolavandero@gmail.com" class="auth_mail}
• 关键词：IGF-1R ; inter-organelle communication ; calcium ; cardiac progenitor stem cells
• 刊名：Trends in Endocrinology and Metabolism
• 出版年：March, 2014
• 年：2014
• 卷：25
• 期：3
• 页码：128-137
• 全文大小：1433 K

文摘

Insulin-like growth factor 1 (IGF-1) signaling regulates contractility, metabolism, hypertrophy, autophagy, senescence, and apoptosis in the heart. IGF-1 deficiency is associated with an increased risk of cardiovascular disease, whereas cardiac activation of IGF-1 receptor (IGF-1R) protects from the detrimental effects of a high-fat diet and myocardial infarction. IGF-1R activates multiple pathways through its intrinsic tyrosine kinase activity and through coupling to heterotrimeric G protein. These pathways involve classic second messengers, phosphorylation cascades, lipid signaling, Ca²⁺ transients, and gene expression. In addition, IGF-1R triggers signaling in different subcellular locations including the plasma membrane, perinuclear T tubules, and also in internalized vesicles. In this review, we provide a fresh and updated view of the complex IGF-1 scenario in the heart, including a critical focus on therapeutic strategies.