The alteration of serine transporter activity in a cell line model of amyotrophic lateral sclerosis (ALS)

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• 作者：Na-Young Lee^a ; Yunha Kim^b ; Hoon Ryu^b ; ^c ; Young-Sook Kang^a ; ^{yskang@sookmyung.ac.kr}
• 关键词：Amyotrophic lateral sclerosis (ALS) ; Motor neuron disease ; d-Serine ; l-Serine
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：29 January 2017
• 年：2017
• 卷：483
• 期：1
• 页码：135-141
• 全文大小：788 K
• 卷排序：483

文摘

The alteration of d-serine levels is associated with the pathogenesis of ALS. The uptake of d-serine is reduced in a motor neuronal cell line model of ALS. In contrast, the uptake of l-serine, precursor of d-serine, was markedly increased in a motor neuronal cell model of ALS. The alteration of d- and l-serine uptakes in ALS is driven by the affinity change of d- and l-serine uptake system.