Antipsychotic drugs induce cell cytoskeleton reorganization in glial and neuronal cells via Rho/Cdc42 signal pathway
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- 作者：Mao-Liang Chena ; cater0656@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Fu-Ming Tsaia ; b ; Ming-Cheng Leea ; Yi-Yin Lina
- 关键词：APDs ; antipsychotic drugs ; ARP2/3 ; actin-related protein 2/3 ; Cdc42 ; cell division control protein 42 homolog ; CNS ; central nervous system ; p-JNK ; c-Jun. N-terminal kinase ; MLC2 ; myosin light chain 2 ; N-WASP ; neural Wiskott&ndash ; Aldrich syndrome protein ; p-MLC2 ; phospho-myosin light chain 2 ; PAK1 ; serine/threonine protein kinase ; PFN1 ; profilin 1 ; Rac ; Ras-related C3 botulinum toxin substrate ; RhoA ; Ras homolog gene family ; member A ; RhoGDI1 ; Rho GDP-dissociation inhibitor 1 ; ROCK1 ; Rho-associa
- 刊名：Progress in Neuropsychopharmacology & Biological Psychiatry
- 出版年：2016
- 出版时间：3 November 2016
- 年：2016
- 卷：71
- 期：Complete
- 页码：14-26
- 全文大小：2152 K
文摘
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APDs increase RhoGDI1 expression and activate RhoA in rat cortex.
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APDs induce MLC2 and p-MLC2 expression regulation in rat cortex.
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APDs activate RhoA in C6 cells and cdc42 in B35 cells.
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APDs regulate d-serine production and p-MLC2 expression in both C6 and B35 cells.
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APDs induce cytoskeleton reorganization and cell migration of C6 and B35 cells.