Synthesis and biological evaluation of C(5)-substituted derivatives of leukotriene biosynthesis inhibitor BRP-7
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- 作者：Serkan Leventa ; Jana Gerstmeierb ; Abdurrahman Olgaç ; a ; Felix Nikelsb ; Ulrike Garschab ; Andrea Carottic ; Antonio Macchiaruloc ; Oliver Werzb ; Erden Banoglua ; banoglu@gazi.edu.tr" class="auth_mail" title="E-mail the corresponding author ; Burcu Ç ; alışkana ; bcaliskan@gazi.edu.tr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Leukotriene ; 5-Lipoxygenase-activating protein ; FLAP ; Benzimidazole ; BRP-7
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2016
- 出版时间：21 October 2016
- 年：2016
- 卷：122
- 期：Complete
- 页码：510-519
- 全文大小：1250 K
文摘
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A series of C(5)-substituted analogues of FLAP inhibitor BRP-7 were synthesized.
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5-Nitrile substitution resulted in the highly active derivative
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Docking studies and molecular dynamic simulations of