Seropositivity to influenza A(H1N1)pdm09 and influenza A (H3N2) and risk of infection in health care workers

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• 作者：G. Nandhini ; S. Sujatha ; ^{sujathasistla@gmail.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Influenza A virus ; Swine influenza ; H1N1 ; Tertiary care center ; Vaccination
• 刊名：Clinical Epidemiology and Global Health
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：4
• 期：1
• 页码：28-32
• 全文大小：349 K

文摘

Health care workers are at an increased risk of infection during influenza outbreaks. This study on seropositivity of influenza A viruses provided an opportunity to evaluate this risk.

Methods

This cross-sectional study was conducted during August–October 2013. Health care workers in a tertiary care center, Pondicherry completed a detailed questionnaire including sociodemographic and professional details, vaccination status, known history of swine or seasonal flu infection and contact with flu infected patients. Serum was collected and hemagglutination inhibition (HI) assaywas performed using reference antigens -influenza A (H1N1) A/California/07/2009, influenza A (H3N2) A/Victoria/361/2011 according to World Health Organization protocol. HI titres ≥40 were considered protective.

Results

Serum samples were received from 138 health care workers. Seropositivity to seasonal influenza A (H3N2) and pandemic influenza A(H1N1)pdm09 was 100% and 83% respectively. There was no association of any sociodemographic factor with seropositivity to influenza A viruses.

Conclusion

Regardless of sociodemographic, professional and vaccination status, most health care workers had seroprotective antibody titers against influenza A viruses, indicating that they are not at an increased risk of infection.