Olanzapine decreased 5-HT2A, 5-HT2C bindings in all frontal brain regions of both male and female juvenile rats.
Risperidone decreased 5-HT2A, 5-HT2C bindings in the prefrontal cortex.
Aripiprazole reduced the 5-HT2A bindings in the male PFC, but had no effects on 5-HT2C bindings.
Early antipsychotic treatment had less effects on dopamine D1/D2 receptor bindings.
Early antipsychotic treatment caused some gender-dependent changes.