Identification of bioactive peptides from a papain hydrolysate of bovine serum albumin and assessment of an antihypertensive effect in spontaneously hypertensive rats
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- 作者：Tomas Lafargaa ; Rotimi E. Alukob ; Dilip K. Raia ; Paula O'Connorc ; Maria Hayesa ; maria.hayes@teagasc.ie" class="auth_mail" title="E-mail the corresponding author
- 关键词：DPP-IV ; dipeptidyl peptidase-IV ; GLP-1 ; glucagon-like peptide-1 ; GIP ; gastric-inhibitory peptide ; ACE-I ; angiotensin-I-converting enzyme ; RAAS ; renin-angiotensin-aldosterone system ; EFSA ; European Food Safety Authority ; BSA ; bovine serum albumin ; MWCO ; molecular weight cut-off ; HPLC ; high performance liquid chromatography ; SHRs ; spontaneously hypertensive rats ; FA ; formic acid ; DMSO ; dimethyl sulfoxide ; ACN ; acetonitrile ; NUFH ; non-ultrafiltrated hydrolysate ; 1UFH ; hydrolysate ultrafiltrated wit
- 刊名：Food Research International
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：81
- 期：Complete
- 页码：91-99
- 全文大小：873 K
文摘
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Utilization of bovine blood proteins for the generation of biologically active peptides
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In silico analysis used for selection of enzymes and proteins for bioactive peptide generation
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Identification of bioactive hydrolysates with in vitro ACE-I inhibitory activity
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Identification of bioactive di- and tri-peptides including the renin inhibitor SLR and the ACE-I inhibitors YY, ER, and FR
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Assessment of hypotensive effects in vivo in spontaneously hypertensive rats