The expanding horizon of MicroRNAs in cellular reprogramming

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• 作者：Yogita K. Adlakha ; ^{yogita@nbrc.ac.in} ; Pankaj Seth
• 关键词：OSK (3 factors) ; OCT4 ; SOX2 ; KLF4 ; OSKM (4 factors) ; OCT4 ; SOX2 ; KLF4 ; MYC ; ESCs ; Embryonic stem cells ; MEFs ; Mouse embryonic fibroblasts ; iPSCs ; Induced pluripotent stem cells ; MBD2 ; methyl DNA binding domain protein 2 ; MECP1/2 ; methyl-CpG binding proteins 1 and 2 ; MiRNA ; MicroRNA ; hHFCs ; human hair follicle cells ; HDFs ; human dermal fibroblasts
• 刊名：Progress in Neurobiology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：148
• 期：Complete
• 页码：21-39
• 全文大小：2861 K
• 卷排序：148

文摘

The role of miRNAs in inducing or suppressing reprogramming is addressed by highlighting them as regulators of pluripotency. In-silico analysis sheds light on unexplored biological processes, pathways and helps in identifying roadblocks to complete reprogramming. The biological significance of miR-302-367 cluster revealed metabolic processes as the highest rated biological processes. A recent approach of direct conversion or transdifferentiation of differentiated cells into neurons by miRNAs is also elaborated.