Sox9-Positive Progenitor Cells Play a Key Role in Renal Tubule Epithelial Regeneration in Mice
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- 作者：Hyun Mi Kang1 ; 2 ; Shizheng Huang1 ; Kimberly Reidy1 ; Seung Hyeok Han1 ; Frank Chinga1 ; Katalin Susztak1 ; ksusztak@mail.med.upenn.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：2 February 2016
- 年：2016
- 卷：14
- 期：4
- 页码：861-871
- 全文大小：5234 K
文摘
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Sox9 expression increases quickly after injury, and most of diving cells express Sox9
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In vitro, Sox9-positive cells showed proliferative and differentiation capacity
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Sox9-positive cells are segment-specific progenitors in the regenerating kidney
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In absence of Sox9, tubule regeneration is altered and fibrosis develops