An apolar Pistacia lentiscus L. leaf extract: GC-MS metabolic profiling and evaluation of cytotoxicity and apoptosis inducing effects on SH-SY5Y and SK-N-BE(2)C cell lines
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- 作者：Simona Piccolellaa ; Paola Noceraa ; Petronia Carilloa ; Pasqualina Woodrowa ; Vincenza Grecoa ; Lorenzo Mantib ; Antonio Fiorentinoa ; Severina Pacificoa ; severina.pacifico@unina2.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：Pistacia lentiscus L. ; GC-MS ; Pentacyclic triterpenes ; Cytotoxicity ; Apoptosis-inducing effects ; Pro-oxidant activity
- 刊名：Food and Chemical Toxicology
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：95
- 期：Complete
- 页码：64-74
- 全文大小：924 K
文摘
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An apolar Pistacia lentiscus leaf extract (Pl-C) was prepared.
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Pl-C was rich in pentacyclic triterpenes and α-tocopherol.
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Pl-C inhibited dose-dependently SH-SY5Y cell viability.
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Pl-C (100 μg/mL) activated caspase-3 and induced disturbance in cell redox balance.
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Apoptotic DNA fragments were detected in Pl-C (100 μg/mL)-treated SH-SY5Y cells.