The contribution of TRPC1, TRPC3, TRPC5 and TRPC6 to touch and hearing
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- 作者：Jane E. Sextona ; jane.sexton.09@ucl.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Terri Desmondsb ; Kathryn Quicka ; Ruth Taylorc ; Joel Abramowitzd ; Andy Forgec ; Corné ; J. Krosb ; e ; Lutz Birnbaumerd ; John N. Wooda
- 关键词：DKO ; double knockout mice ; QuadKO ; quadruple knockout mice
- 刊名：Neuroscience Letters
- 出版年：2016
- 出版时间：1 January 2016
- 年：2016
- 卷：610
- 期：Complete
- 页码：36-42
- 全文大小：1632 K
文摘
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The contribution of multiple TRPC channels on mechanosensory function is demonstrated.
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We observe a critical role for TRPC channels in touch sensation.
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TRPC channels contribute to cutaneous and auditory mechanosensation in a combinatorial manner, but have no direct role in cochlear mechanotransduction.