Protopanaxatirol type ginsenoside Re promotes cyclic growth of hair follicles via inhibiting transforming growth factor β signaling cascades
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- 作者：Zheng Lia ; Seung-Wook Ryub ; c ; ryus@kaist.ac.kr" class="auth_mail" title="E-mail the corresponding author ; Jungsul Leec ; d ; Kyungsun Choid ; Sunchang Kima ; b ; e ; Chulhee Choib ; c ; d ; cchoi@kaist.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Hair growth ; Ginsenoside Re ; Minoxidil ; TGF-β ; SMAD ; ERK
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：19 February 2016
- 年：2016
- 卷：470
- 期：4
- 页码：924-929
- 全文大小：1227 K
文摘
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Ginsenoside Re induced premature entry of telogen hair follicles into anagen and enhanced anagen in a mouse model.
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Ginsenoside Re stimulated hair shaft growth in cultured vibrissa hair follicles ex vivo.
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Ginsenoside Re inhibited TGF-β signaling via downregulation of transcription factors SMAD3 in nude mice.
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Ginsenoside Re suppressed TGF-β-induced ERK phosphorylation in HeLa cells.