Bacoside-A, an anti-amyloid natural substance, inhibits membrane disruption by the amyloidogenic determinant of prion protein through accelerating fibril formation
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- 作者：Ravit Malisheva ; Sukhendu Nandia ; Sofiya Kolushevab ; Shira Shaham-Nivc ; Ehud Gazitc ; d ; Raz Jelineka ; b ; razj@bgu.ac.il" class="auth_mail" title="E-mail the corresponding author
- 关键词：Bacoside ; Prion protein ; PrP(106&ndash ; 126) ; Amyloid peptides ; Amyloid fibrils ; Membrane interactions
- 刊名：Biochimica et Biophysica Acta (BBA)-Biomembranes
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：1858
- 期：9
- 页码：2208-2214
- 全文大小：921 K
文摘
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Bacoside-A inhibits membrane interactions of prion protein amyloid fragment.
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Bacoside-A/PrP(106–126) interactions in vesicle solutions enhance fibril formation.
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Lower amyloid toxicity linked to inhibited fibrillation and membrane binding.
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Results might shed light on putative therapeutic effects of bacoside-A.