- 作者：Hamid Khakshoor ; Mohammad Etezad Razavi ; Ramin Daneshvar ; Mohammad Taghi Shakeri ; Majid Farrokh Ghate ; Haleh Ghooshkhanehi
- 刊名：American Journal of Ophthalmology
- 出版年：2010
- 出版时间：August 2010
- 年：2010
- 卷：150
- 期：2
- 页码：193-198
- 全文大小：619 K
Purpose
To evaluate and compare the recurrence rates and complications between 2 therapeutic methods for primary pterygium: subconjunctival injection of mitomycin C (MMC) 1 month before bare scleral excision and conjunctival rotational flap with intraoperative MMC use.Design
Prospective, interventional, randomized clinical trial.
Methods
setting: Institutional clinical trial in a tertiary, specialty eye hospital. study population and intervention: We included 82 eyes diagnosed with primary pterygium and randomly allocated them into 2 groups. Group A consisted of 36 eyes treated with subconjunctival injection of 0.02 % MMC 1 month before bare scleral excision, and group B comprised 46 eyes that underwent conjunctival rotational flap with intraoperative 0.02 % MMC for 2 minutes. Follow-up periods were at least 12 months (range, 12 to 18 months). main outcome measure: Recurrence and complication rate in each arm of study.
Results
During the 1-year follow-up, 2 cases of clinical recurrence in third and sixth month of follow-up occurred in group B (recurrence rate, 4.3 % ). In group A, there was no clinically significant recurrence, but 2 cases of hypovascularity and whitening of sclera at the site of pterygium excision was observed. There was no other serious complication. There was no statistically significant difference between groups for recurrence rate, mean age, sex, or pterygium area.
Conclusions
Subconjunctival injection of MMC 0.02 % (0.1 ml of 0.02 % solution) 1 month before bare scleral excision is a quick, easy, and safe surgical procedure and is at least as effective as conjunctival rotational flap with intraoperative MMC for 2 minutes.