“All that glisters is not gold”: Ultrafiltration and free thyroxine measurement: With apologies to W Shakespeare

详细信息    查看全文

• 作者：John E.M. Midgley^a ; ^{je.midgley@virgin.net}
• 关键词：Free thyroxine ; Ultrafiltration ; Measurement ; Artefacts
• 刊名：Clinical Biochemistry
• 出版年：2011
• 出版时间：February 2011
• 年：2011
• 卷：44
• 期：2-3
• 页码：151-153
• 全文大小：142 K

文摘

Objective

To examine the merits of measuring free analytes by ultrafiltration using either diluted or undiluted serum.

Results

Confidence in the accuracy of measurements is affected both by problems identified in current systems using semipermeable membranes, the sensitivity of the system to artefacts and comparisons with other imperfect assays.

Conclusion

All “gold standard” methods must robustly obey sound physicochemical principles if valid conclusions are to be drawn.