Children with Haemophilus influenzae type b (Hib) vaccine failure have long-term bactericidal antibodies against virulent Hib strains with multiple capsular loci
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- 作者：Kelly Townsend-Paynea ; Shamez N. Ladhanib ; c ; shamez.ladhani@phe.gov.uk" class="auth_mail" title="E-mail the corresponding author ; Helen Findlowa ; Mary Slackd ; e ; Ray Borrowa ; f
- 关键词：Haemophilus influenzae type b ; Capsular operon ; Vaccine ; Failure
- 刊名：Vaccine
- 出版年：2016
- 出版时间：25 July 2016
- 年：2016
- 卷：34
- 期：34
- 页码：3931-3934
- 全文大小：250 K
文摘
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We tested SBA activity in 127 children with Hib vaccine failure in the UK.
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SBA activity was assessed against Hib strains expressing 1–5 capsulation locus copies.
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There was no association between SBA titres and number of capsulation locus copies.
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Children with Hib vaccine failure are protected against multiple-copy Hib strains.