Nanoparticles-protein interaction: Role in protein aggregation and clinical implications

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• 作者：Romana Parveen ; Tooba Naz Shamsi ; Sadaf Fatima ; ^{amu.jmi@rediffmail.com} ; ^{sfatima1@jmi.ac.in}
• 关键词：Nanoparticles ; Nanotechnology ; Protein binding ; Circular dichroism ; Adsorption ; Protein folding/refolding ; Protein aggregation ; Cyclodextrins ; Protein structure ; Nanospheres
• 刊名：International Journal of Biological Macromolecules
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：94
• 期：part_PA
• 页码：386-395
• 全文大小：1436 K
• 卷排序：94

文摘

The review details folding and misfolding of protein and its clinical implications. Neurodegenerative diseases are also and outcome of protein misfolding and aggregation. Interaction of nanoparticles with proteins alters the protein conformation and prevents protein aggregation. Currently nanoparticles are employed as artificial chaperones and for detection of protein-folding intermediates. Nanoparticles can be used in developing targeted novel treatment for fatal diseases.