Neurodegenerative diseases linked to misfolded proteins and their therapeutic approaches: A review
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- 作者：Hena Khanam ; henak055@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Abad Ali ; Mohd Asif ; Shamsuzzaman ; shamsuzzaman9@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Protein misfolding ; Neurodegenerative ; Alzheimer's disease ; Perkinson's disease ; Prions
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2016
- 出版时间：29 November 2016
- 年：2016
- 卷：124
- 期：Complete
- 页码：1121-1141
- 全文大小：971 K
文摘
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Neurodegenerative diseases are mainly characterized by the massive deposition of misfolded protein aggregates.
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There is no effective cure to treat these disorders, hence therapeutic tools able to counteract them, are actively sought.
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In this review we have examined recent progress in the area of neurodegenerative drug discovery.