Polymorphism T ?#xa0;C of gene CYP17 promoter and polycystic ovary syndrome risk: A meta-analysis

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• 作者：Ya Li^a ; ¹ ; Fei Liu^b ; ¹ ; Shan Luo^a ; Han Hu^a ; Xiao-Hong Li^a ; Shang-Wei Li^a ; ^{lishangwei688@foxmail.com}
• 关键词：PCOS ; polycystic ovary syndrome ; CYP17 ; 17¦Á-hydroxylase ; OR ; odds ratio ; CI ; confidence interval ; SNP ; single nucleotide polymorphisms ; HWE ; Hardy&ndash ; Weinberg equilibrium
• 刊名：Gene
• 出版年：2012
• 出版时间：1 March 2012
• 年：2012
• 卷：495
• 期：1
• 页码：16-22
• 全文大小：557 K

文摘

The T ?#xA0;C polymorphism of CYP17 gene has been inconsistently associated with polycystic ovary syndrome (PCOS) risk. We examined the association by performing a meta-analysis. Two investigators independently searched the Medline, Embase, CNKI, and Chinese Biomedicine Databases. Summary odds ratios (ORs) and 95 % confidence intervals (95 % CIs) for CYP17 polymorphism and PCOS were calculated in a fixed-effects model and a random-effects model when appropriate. The pooled ORs were performed for co-dominant model (CC vs. TT, TC vs. TT), dominant model (CC + TC vs. TT), and recessive model (CC vs. TC + TT). Subgroup analyses were performed by ethnicity, country, Hardy-Weinberg equilibrium (HWE) in controls and study sample size. This meta-analysis included 10 case-control studies, which included 1321 PCOS cases and 1017 controls. Overall, the variant genotypes (CC and TC) were not associated with PCOS risk, compared with the wild-type TT homozygote. Similarly, no associations were found in the dominant and recessive models. Stratified analyses by ethnicity/country also detected no significant association. However, limiting the analysis to the studies within HWE, a significantly increased risk was observed (TC vs. TT, OR = 1.44, 95 % CI = 1.10-1.88; dominant model, OR = 1.41, 95 % CI = 1.10-1.81). Moreover, when stratifying by study sample size, a significantly elevated risk was found among small sample studies (?#xA0;200 subjects), but not among large sample studies (> 200 subjects). This meta-analysis suggests that the CYP17 T/C polymorphism may be not associated with PCOS risk, while the observed increase in risk of PCOS may be due to small-study bias.