Redox biology of hydrogen sulfide: Implications for physiology, pathophysiology, and pharmacology

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• 作者：Asaf Stein ; Shannon M. Bailey
• 关键词：ARE ; Antioxidant response element ; CO ; Carbon monoxide ; CBS ; Cystathionine-尾-synthase ; CGL ; Cystathionine-纬-lyase ; CcO ; Cytochrome c oxidase ; GSH ; Glutathione ; HSP ; Heat shock protein ; H2S ; Hydrogen sulfide ; HIF ; Hypoxic inducible factor ; IL-1尾 ; Interleukin 1 beta ; IL-6 ; Interleukin 6 ; 3-MST ; 3-mercaptopyruvate S-transferase ; NO ; Nitric oxide ; NF-魏B ; Nuclear factor light chain enhancer of activated B cells ; oxLDL ; Oxidized low density lipoprotein ; PAG ; Propargylglycine ; PGE2 ; Prostaglandin E
• 刊名：Redox Biology
• 出版年：2013
• 年：2013
• 卷：1
• 期：1
• 页码：32-39
• 全文大小：619 K

文摘

Hydrogen sulfide (H₂S) has emerged as a critical mediator of multiple physiological processes in mammalian systems. The pathways involved in the production, consumption, and mechanism of action of H₂S appear to be sensitive to alterations in the cellular redox state and O₂ tension. Indeed, the catabolism of H₂S through a putative oxidation pathway, the sulfide quinone oxido-reductase system, is highly dependent on O₂ tension. Dysregulation of H₂S homeostasis has also been implicated in numerous pathological conditions and diseases. In this review, the chemistry and the main physiological actions of H₂S are presented. Some examples highlighting the cytoprotective actions of H₂S within the context of cardiovascular disease are also reported. Elucidation of the redox biology of H₂S will enable the development of new pharmacological agents based on this intriguing new redox cellular signal.