Sa.75. Antigen Presentation by Lymph Node Stroma: Potential for Tolerogenic Immunotherapy

详细信息    查看全文

• 作者：Ai-ris Collier ; Erika Reynoso ; Melissa Tjota ; Shannon Turley
• 关键词：Urotensin II ; UT receptor ; Structure– ; activity study ; HEK293_rUT ; Rat aorta
• 刊名：Clinical Immunology
• 出版年：2008
• 出版时间：2008
• 年：2008
• 卷：127
• 期：Supplement 1
• 页码：S105
• 全文大小：36 K

文摘

In the present study we describe the synthesis and biological evaluation of 24 analogues of the urotensin II (U-II) fragment U-II(4-11) substituted in position 4 with coded and non-coded aromatic amino acids. All of the new analogues behaved as full U-II receptor (UT) agonists. Our results indicated that aromaticity is well tolerated, size, length and chirality of the side chain are not important, while substituents with a nitrogen atom are preferred. Thus acylation of U-II(5-11) with small groups bearing nitrogen atoms could be instrumental in future studies for the identification of novel potent UT receptor ligands.