Interleukin-13 stimulates MUC5AC expression via a STAT6-TMEM16A-ERK1/2 pathway in human airway epithelial cells
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- 作者：Yanling Qin1 ; Youfan Jiang1 ; Awais Shafiq Sheikh ; Shanshan Shen ; Jing Liu ; Depeng Jiang ; depengjiang@sina.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Transmembrane protein 16A ; Extracellular regulated kinase ; Signal transducer and activator of transcription 6 ; Mucin 5AC
- 刊名：International Immunopharmacology
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：40
- 期：Complete
- 页码：106-114
- 全文大小：1514 K
文摘
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IL-13 regulates TMEM16A expression via STAT6 signaling pathway.
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ERK1/2 signaling pathway is required for TMEM16A mediated mucus production.
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Chloride channel activity of TMEM16A is required for MUC5AC expression.