Immunogenicity of a DNA vaccine of Avian Reovirus orally delivered by attenuated Salmonella typhimurium

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• 作者：Junjie  ; Wan^a ;   ; ¹ ; Cunwei  ; Wang^a ;   ; ¹ ; Xintian  ; Wen^a ; Xiaobo  ; Huang^a ; ShanShan  ; Ling^b ; Yong  ; Huang^a ; Sanjie  ; Cao^a ;   ; ^{csanjie@gmail.com}
• 关键词：Attenuated Salmonella typhimurium ; Avian Reovirus ; ¦ÒC Gene vaccine ; Immunization
• 刊名：Research in Veterinary Science
• 出版年：2011
• 出版时间：December 2011
• 年：2011
• 卷：91
• 期：3
• 页码：382-383
• 全文大小：139 K

文摘

This study aimed to assess the ability of a Salmonella typhimurium-mediated Avain Reovirus DNA vaccine in eliciting antibody production. Six-day-old SPF chickens were orally immunized with SL7207 (pVAX-¦ÒC) twice at 2-week interval, detectable antibody was generated 2 weeks after immunization and was significantly higher than the control groups (P < 0.01) and ten chickens (66.7 % ) were considered safe in the subsequent challenge. These results show that SL7207 (pVAX-¦ÒC) can induce protective antibody in chickens and the newly-constructed vaccine is also effective in protection chickens against ARV infection.