Oxidative Homeostasis Regulates the Response to Reductive Endoplasmic Reticulum Stress through Translation Control
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- 作者：Shuvadeep Maity1 ; 4 ; Asher Rajkumar1 ; 3 ; 4 ; Latika Matai1 ; 3 ; 4 ; Ajay Bhat1 ; 3 ; Asmita Ghosh1 ; 3 ; Ganesh Agam1 ; Simarjot Kaur1 ; Niraj R. Bhatt1 ; 3 ; Arnab Mukhopadhyay2 ; 5 ; Shantanu Sengupta1 ; 3 ; 5 ; Kausik Chakraborty1 ; 3 ; 5 ; kausik@igib.res.in" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：19 July 2016
- 年：2016
- 卷：16
- 期：3
- 页码：851-865
- 全文大小：5012 K
文摘
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Oxidative quality control pathways are essential to counteract reductive ER stress
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Failure of oxidative quality leads to accumulation of peroxide during ER stress
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Non-canonical bimodal translation regulation by peroxide blocks the ER stress response
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This is prevented by activation of canonical PERK-dependent translation regulation