The up-regulation of long non-coding RNA CCAT2 indicates a poor prognosis for prostate cancer and promotes metastasis by affecting epithelial-mesenchymal transition
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- 作者：Jinfeng Zhenga ; 1 ; Shaoxiong Zhaob ; 1 ; Xiaolong Hec ; Zhili Zhenga ; Weibin Baid ; Youlin Duana ; Shanlin Chenge ; Juncai Wangb ; wangjun201605@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Xucheng Liuf ; liuxucheng1963@126.com" class="auth_mail" title="E-mail the corresponding author ; Gang Zhangg ; zhanggang196811@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Long non-coding RNA ; CCAT2 ; Prostate cancer ; Prognosis
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：25 November 2016
- 年：2016
- 卷：480
- 期：4
- 页码：508-514
- 全文大小：1118 K
文摘
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LncRNA CCAT2 is identified with overexpression in prostate cancer tissues and cell lines.
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High expression of lncRNA CCAT2 can be an independent prognostic factor for overall survival and progression-free survival.
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Knockdown of lncRNA CCAT2 can inhibit cell growth, migration, and invasion in vitro study.
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Knockdown of lncRNA CCAT2 stimulates metastasis of prostate cancer cell through regulating EMT-associated gene expression including N-cadherin, Vimentin and E-cadherin.